The Vitamin D Response Element-binding Protein
نویسندگان
چکیده
منابع مشابه
Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling.
Transcriptional regulation by hormonal 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] involves occupancy of vitamin D response elements (VDREs) by the VDRE binding protein (VDRE-BP) or 1,25(OH)(2)D(3)-bound vitamin D receptor (VDR). This relationship is disrupted by elevated VDRE-BP, causing a form of hereditary vitamin D-resistant rickets (HVDRR). DNA array analysis showed that of 114 genes regu...
متن کاملVitamin D Binding Protein and Vitamin D Levels
1 Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China 2 Clinical Research, Diabetes and Endocrinology, Merck Research Laboratories, 126 East Lincoln Avenue, RY34B-148, Rahway, NJ 07065-0900, USA 3Department of Nutritional Science, Rutgers University, New Brunswick, NJ 08901, USA 4Division of Endocrinology, Metabolism an...
متن کاملVitamin D-binding protein prevents vitamin D deficiency and presents vitamin D for its renal activation.
Two mouse models in which the vitamin D-binding protein (DBP) or megalin, a DBP receptor, were knocked out have recently confirmed that DBP is essential for normal vitamin D homeostasis, and have revealed a major pathway for vitamin D activation (1, 2). DBP is also known as the group-specific component of serum (Gc-globulin). It is a highly polymorphic 58 kDa glycoprotein, which has been used a...
متن کاملImmunonephelometric assay of vitamin D-binding protein.
An automated immunonephelometric assay was developed to measure vitamin D-binding protein (DBP) in serum. The assay is described for the Behring Nephelometer System, which uses rabbit anti-DBP antiserum and purified human DBP. The detection limit is 0.05 g/L (0.86 mumol/L), and the working range is less than or equal to 1.60 g/L (27.59 mumol/L). Intra- and interassay CVs of 2.0% and 2.8-3.8% co...
متن کاملVitamin D-dependent Calcium-binding Protein
A method of purification of a vitamin D-dependent calciumbinding protein from chick intestinal mucosa is described. The purification procedure involved the use of ammonium sulfate precipitation, gel filtration on Sephadex G-100, and preparative disc electrophoresis. The assay system for calcium-binding protein is based upon the competition between calcium-binding protein and an ion exchange res...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.m007117200